Multi- and many-core microprocessors are being deployed in a broad spectrum of applications including Clusters, Clouds and Grids. Both conventional multi- and many-core processors, such as Intel Nehalem and IBM Power7 processors, and unconventional many-core processors, such as NVIDIA Tesla and AMD FireStream GPUs, hold the promise of increasing performance through parallelism. However, GPU approaches in parallelism are distinctly different from those of conventional multi- and many-core processors, which raises new challenges: For example, how do we optimize applications for conventional multi- and many-core processors? How do we reengineer applications to take advantage of GPUs' tremendous computing power in a reasonable cost-benefit ratio? What are effective ways of using GPUs as accelerators? The goals of this workshop are to discuss these and other issues and bring together developers of application algorithms and experts in utilizing multi- and many-core processors. Accepted papers will be published in the CCGRID proceedings. Selected papers will be published in a special issue of the Journal Concurrency and Computation: Practice and Experience. Papers submission deadline: Jan 16, 2010.